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Interview with Prof. Lindsey Allan

589 Views   1 Year Ago
Watch Prof. Lindsey Allan In Conversation with Dr. Prathima Radhakrishnan. Here is the inside story of this true pioneer who changed the way we understand Fetal Cardiology today.

CNS Anomalies in 2nd Trimester

In this clinical video Dr Prathima Radhakrishnan sheds some light on brain anomalies in the 2nd trimester. Here the cerebral hemisphere appears widely separated with a large cystic area suggesting an absence of cerebral vermis i.e., the Vermian agenesis. Additionally, there appears a disruption of cranium with part of the brain herniating out. In such a scenario, it is preferred to check for chromosomal abnormalities and genetic syndromes like Dandy-Walker malformation, Vermian agenesis. However Dandy-Walker malformation is not detectable before 16 weeks. Also, it is important to ensure that the frequently occurring little cysts in the choroid plexus of cerebral ventricles are well within the choroid plexus. They are markers of Trisomy 18
2109+ Views
By - Dr. Prathima Radhakrishnan
2 Years Ago

20 Week Fetal Brain

In this clinical video Dr Prathima Radhakrishnan talks about a 20 week fetal brain. Here the brain structure looks exposed and herniated out of the skull appearing like a lady’s bun. There is also marked disruption of intracranial structures. Prognosis in such a case is very poor and it’s advisable to look for other abnormalities like polycystic kidneys and polydactyly and Meckel-Gruber syndrome. It is important to pick up such abnormalities in the 1st trimester while the cranium is still intact.
1134+ Views
By - Dr. Prathima Radhakrishnan
2 Years Ago

22 Weeks Fetal brain

In this clinical video Dr Prathima Radhakrishnan discusses about a 22 weeks fetal brain. This case is a variant of Semi-Lobar Holoprosencephaly.
1125+ Views
By - Dr. Prathima Radhakrishnan
2 Years Ago

Semi-lobar Holoprosencephaly

Semi-lobar holoprosencephaly is characterized by the partial segmentation of the ventricles and the cerebral hemispheres posteriorly with incomplete fusion of the thalami. The facial defects associated with this type are milder when compared to the alobar type. Chromosomal abnormalities have been associated with holoprosencephaly which include trisomy 13, trisomy 18, deletion of 2p, deletion of 7q, partial monosomies of 13q
1237+ Views
By - Dr. Prathima Radhakrishnan
3 Years Ago

Cerebellum and Cisterna magna

On a trans-cerebellar plane, the frontal horns of the lateral ventricles, CSP, thalami, cerebellum and cisterna magna can be visualized. The cerebellum appears as a butterfly shaped structure formed by the round cerebellar hemispheres joined in the middle by the slightly more echogenic cerebellar vermis. The cisterna magna or cisterna cerebello-medullaris is a fluid filled space posterior to the cerebellum . The surface of the cerebral hemisphere in the second trimester when visualized is still smooth, since the sulci and the gyri develop only later on. The Sylvian fissure is seen which is wide and hence the lobe of insula can be recognized. The posterior fossa with the cerebellum and the cistern magna are also seen .
1234+ Views
By - Dr. Prathima Radhakrishnan
3 Years Ago

Ventriculomegaly

Dilatation of lateral ventricles without the increase in intracranial pressure is termed as ventriculomegaly. With a prevalence rate of 0.3 to 1.5 per 1000 live births, it is the most common congenital CNS anomaly that can be diagnosed during a routine fetal anomaly scan at 18 to 22 weeks gestation . Ventriculomegaly is diagnosed when the width of one or both ventricles measured at the level of glomus of the choroid plexus (atrium), is greater than or equal to 10 millimeters. Depending upon the degree of dilatation, ventriculomegaly can be mild/ borderline or severe. It is characterized as severe when the dilatation is greater than 15mm and as mild when the dilatation ranges between 10 to 15 mm.
1664+ Views
By - Dr. Prathima Radhakrishnan
3 Years Ago

Absent Nasal Bone

Absent nasal bone is reported to be a sonographic marker for of Down Syndrome (DS) in the first trimester. In a normal fetus, the nasal bone is histologically apparent at a crown- rump length of 42 mm corresponding to the 11th week of gestation. According to a study, in fetuses with DS the nasal bone growth does not appear to increase with advancing gestational age.
1670+ Views
By - Dr. Prathima Radhakrishnan
3 Years Ago

Iniencephaly

Disorders related to the non-closure of the neural tube are categorized under the neural tube defect spectrum. Iniencephaly is one such major neural tube defect included in the category. It is one of the rarest neural tube defects and is characterized by a triad of occipital bone defects, cervical dysraphism and fixed retroflection of the fetal head.
1240+ Views
By - Dr. Prathima Radhakrishnan
3 Years Ago

Trisomy 13

Trisomy 13 is the third most common trisomic chromosomal abnormality after trisomies 18 and 21, in live born infants
1441+ Views
By - Dr. Prathima Radhakrishnan
3 Years Ago